Combat Migraines with Isotonic Antioxidants

Woman SoldierMigraines plague approximately 30 million people in the United States with 75% of that number consisting of women.

The treatment of migraines has spurred the creation of a myriad of pain management centers, medications, books, diets, procedures and approaches.  Addressing the physiological and/or environmental causes and then determining the appropriate solution can be daunting at best. Fortunately, many people have found relief from migraines by using nutritional antioxidants and anti-inflammatories.

Free radicals destroy and damage cells. Our bodies are equipped to handle free radicals to a certain degree, but factors such as illness, toxins, and stress can overwhelm the normal production of cellular antioxidants. This results in an imbalance that can set the stage for migraines. Supporting cellular function and immune response with potent and well-researched antioxidants can not only inhibit migraines, it also contributes to disease resistance and anti-aging.

Using isotonic formulas are a terrific way of ingesting anti-inflammatories and antioxidants. Isotonic solutions are the perfect balance of solids to liquids which allows them to pass rapidly from the stomach to the small intestine for maximum absorption.

Some highly effective anti-inflammatories and antioxidants that migraine sufferers are often lacking in are:

  • Magnesium and Calcium
  • B-Complex
  • Oligomeric Proanthocyanidins (OPC’s)
  • Vitamin D
  • Coenzyme Q10 (CoQ10)
  • L-Tryptophan
  • Omega 3 Fish Oils

Fortunately all of these recommendations are available through SHOP.COM and meet these high standards. Drinkable, delicious and up to 95% absorbed these Isotonix® products, along with the others, are amazingly effective.

Isotonix Magnesium
Isotonix® Calcium Plus

Isotonix® Activated B-Complex
Isotonix OPC-3®
Isotonix® Vitamin D with K2
Isotonix® Coenzyme Q10
Isotonix® L-Tryptophan
HeartHealth™ Essential Omega 3 Fish Oil with Vitamin E

Wondering if cholesterol lowering drugs are making you stupid?… Study shows they may be

Old Worried GuyThe Wall Street Journal published the first allegations of cholesterol lowering statin drugs being associated with dementia. In the article, Dr. Orli Etingin (vice chairman of medicine at New York Presbyterian Hospital-Weill Cornell Medical Center) stated that Lipitor “makes women stupid.”

Dr. Etingin was referring to several of her patients using statins that were unable to focus, recall words and displayed other cognitive deficiencies. According to Dr. Etingin, the impairments vanished when use of the statin drug was discontinued and returned when the statins were reintroduced.

Two British experts in Alzheimers and dementia, Louise Morse and Roger Hitchins, write that the most common causes of memory loss they see in both men and women are due to depression, poor nutrition and statin drug use.

Some doctors have suspected that certain cognitive disruptions are triggered when statin drugs (like Simvastatin) cross the blood brain barrier and interfere with the central nervous system. Another possibility is that because the brain is composed largely of cholesterol, lowering cholesterol could slow thought and memory connections. Statins have also been linked to abnormal tau proteins forming in the brain, as seen in Alzheimer’s, Parkinson’s and Lou Gehrig’s disease.

A new study may provide even more disturbing evidence as to the impact statins have on cognitive function.

This fascinating study published July 2008 in Glia by Dr. Steven Goldman and Dr. Fraser Sim discovered that statin drugs inhibit a specific type of brain cell.

These specialized brain cells are called glial progenitor cells. Glial progenitor cells function much like stem cells. They spring into action when the brain has experienced some type of distress and transform into any type of cell needed by the brain. These adaptive cells help restore white matter after strokes, infection, trauma, or inflammation brought on by the aging process, or diseases like multiple sclerosis.

Statins negatively impact glial progenitor cells by switching off their adaptive capabilities. After statin exposure the glial progenitor cells permanently became oligodendrocytes cells.

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CoQ10 – Did you know statins drugs BLOCK this Essential Heart Energy Catalyst?

heart powerCoenzyme Q10 (CoQ10) is a vitamin-like substance naturally secreted by liver enzymes in our bodies. CoQ10 initiates cellular energy production. Critical systems (like the heart, brain and liver) rely on this energy to maintain proper functioning. CoQ10 is a biochemical catalyst that supplies vital energy.

The interesting thing about a catalyst is that it initiates an event, but is not consumed nor incorporated into the activity. Consequently, a biochemical catalyst can perform its function repeatably. Over 90% of the cellular energy generated in the human body is produced this way.

The energy that CoQ10 initiates becomes an organic molecule called adenosine triphosphate (ATP). ATP is known as the ‘energy currency of life’ because all cellular functions need ATP to store or transport their energy requirements.

Cholesterol is a soft waxy substance that composes over 50% of all cell membranes. Cholesterol is necessary for regulating hormone activity, breaking down fats, building bone, enabling immune response, plus absorbing vital nutrients like vitamin D and calcium. We get cholesterol from food and from enzymes produced by the liver.

Statin drugs lower cholesterol by blocking the production of a natural liver enzyme called HMG-CoA reductase. This enzyme enables cholesterol and CoQ10 production. Statins work by attacking HMG-CoA in the liver, which forces the liver to pull cholesterol requirements from the blood. Dr. Gerald Gau (a cardiologist and cholesterol management expert at Mayo Clinic) states that “When you start a statin, your coenzyme Q10 level in your blood drops by 50 percent.” This may explain why over 72% of U.S. cardiologists polled recommend dietary supplements.

A common side effect for people who use statins is muscle pain and weakness called ‘myalgia‘ or ‘myopathy‘. A double-blind study published in 2007 found that supplementing with coenzyme Q10 for 30 days reduced myopathy by 40%. Beatrice Golomb at the University of California in San Diego also identified memory problems and dementia-like symptoms in patients using statins.

Statins definitely reduce unhealthy cholesterol levels, but they also reduce very healthy and desirable CoQ10 as well. Insufficient levels of CoQ10 may be a contributing factor in the high rates of congestive heart failure among statin drug users. Additional adversaries to cardiovascular health are oxidation and arterial inflammation.

Karl Folkers was a chemist for Merck (a large pharmaceutical supplier of statin medications). Dr. Folkers warned that prescribed statin drugs should include supplemental CoQ10 to prevent unintended damage to the patient.

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The Power of Isotonic Formulas Compared to Tablets

In 2009 a group of researchers in Italy conducted a study to see if an isotonic formula of a known highly effective Tablets vs liquidsantioxidant behaved differently on the body compared to the same antioxidant in tablet form.

Isotonix OPC-3® is a powdered antioxidant blend that when mixed with the appropriate amount of water becomes “isotonic“.  Isotonic means “same concentration” and is an ideal ratio between solid and liquids that our bodies convert what we ingest into before it can pass into the small intestine.

The four hour test compared Isotonix OPC-3® in a tablet form to Isotonix OPC-3® in its standard isotonic form.  The amount of water that was consumed with the tablet was equal to the amount of water used in the isotonic version.

Results of the test were startling. Levels of free radicals were measured in the blood plasma of test subjects.  The isotonic OPC-3® reduced free radicals six times more in just 10 minutes compared to the tablet version. The tablet form did eventually reduce free radicals substantially as well, but seriously lagged behind the isotonic form thorough out the four hour test .

Researchers concluded that “the findings demonstrate that the flavonoid mixture provided in isotonic OPC-3® is significantly more bio-available in humans, in terms of antioxidant activity than an equivalent mixture in tablet form.”  Overall the isotonic OPC-3® formulation resulted in a stronger antioxidative effect than an equivalent tablet form.

The results of this test highlight the importance of leveraging the advantage of isotonic formulas for established nutritional supplements like: Isotonix® Coenzyme Q10, Isotonix® Resveratrol, ORAC formulas, Isotonix® Vitamin D with K2, Isotonix® Calcium Plus, B Complex, Vitamin C, Acai, Probiotics, Isotonix® OPC-3 Beauty Blend, Multivitamins, Isotonix® Prenatal Multivitamin, Children’s vitamins, Digestive Enzymes, L-Tryptophan, Blood SugarVision formulas, Anti-aging and Joint Health Formulas. Reducing the amount of work the body needs to do in order to receive the nutritional benefits of these products provides significant “bottom line” results.

Cognitive deterioration may be prevented or reversed with Resveratrol

old-guy-eating-grapesThe aging process, along with several neurodegenerative diseases, causes synaptic deterioration in the brain.  As neurons and brain cells die off, connections are lost impacting learning and memory retention.  Doctors studying Alzheimer’s and other types of age-related dementia are encouraged by a new study on how resveratrol reversed cognitive deterioration in laboratory tests.

In addition to protecting cell health and longevity, SIRT1 is a gene that our bodies trigger when under various types of stress.  SIRT1 activation was initiated in mice that had developed comparable human neurodegenerative diseases.  The mice were treated with resveratrol, which reduced the rate of neuron and cell death and restored learning abilities back to the same level as the normal healthy mice.

“Thus, resveratrol is not only neuroprotective, it also improves cognitive function after severe neurodegeneration,” says Li-Huei Tsai, the research team leader and professor of neuroscience at MIT.

Previously it was thought that resveratrol could not cross the blood brain barrier, however a study done in 2002 indicated otherwise.  In fact, the final summary line stated:  “This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury.” (An ischemic injury is caused by insufficient oxygen or blood flow).

Resveratrol offers yet another safe and natural benefit that could actually improve cognitive function in cases of neurodegenerative disease.

Isotonix® Resveratrol

Resveratrol increases repair and protection of cells by 8 fold

Resveratrol is a potent antioxidant compound found in red wine grape skins and seeds. Resveratrol is also found in various amounts in several other types of plants and acts as a protective agent defending the plant from harmful environmental elements.

Several studies show that resveratrol also enhances human immune function and potential longevity. Well, the news on resveratrol continues to pour in with yet another significant benefit provided by this compound being touted in a new study.

A normal function that cells perform is folding proteins.  When cells misfold proteins and the immune system doesn’t catch them, the misfolded proteins set the stage for trouble.

Cells that experience stress, respond by producing “heat-shock proteins”.  These proteins were called SIRT1. These SIRT1 heat-shock proteins were given that name when it was observed that cells exposed to elevated temperatures generated these special proteins to protect and repair DNA and extend the life of the cell. Cells with SIRT1 activated are stronger, live longer and continue to perform their functions under stress.

Other types of cellular stress like calorie reduction and oxygen-deprivation also triggers SIRT1.  Resveratrol has shown a unique ability to stimulate SIRT1 production by as much as 8 fold without the presence of typical cell stress like heat, food reduction or reduced oxygen.

Resveratrol is plant compound found in grapes that has antioxidant abilities which neutralize free radicals and has demonstrated cancer preventative properties. By triggering SIRT1 production, it holds the potential for increasing life span by protecting cells and inhibiting age related disease.

Neurodegenerative diseases like Type II diabetes, Alzheimer’s and Parkinson’s all present significant amounts of misfolded protein cellular damage.  When SIRT1 levels fall cells are unable to properly respond to stress and systems of the body start to fail.  This also happens during the aging process.

According to research team leader, Richard I. Morimoto, professor of Northwestern’s Weinberg College of Arts and Sciences “When SIRT1 levels are high, you are in a high-protection mode”. Resveratrol contributes to high SIRT1 levels.

“We now have a powerful way to think about addressing neurodegenerative diseases,” said Morimoto. “We have identified a pathway that can be manipulated to alter lifespan. Discovering this new basis for therapeutics is very exciting.”

Isotonix® Resveratrol

Isotonic – a better way of absorbing nutrients

liquidsThe term “isotonic” means “same concentration”. This condition occurs when the amount of dissolved particles inside of a semi-permeable membrane equals the amount of dissolved particles on the outside of that membrane. Body fluids like tears, blood plasma, and lymph all have varying degrees of tonicity.

When we eat food or swallow supplements, the stomach uses muscle contractions and secretes extra fluids (or absorbs excess fluids) until the contents reach an optimum ratio between the solids and liquids. At that point the solution is in an isotonic state and is ready to cross semi-permeable membranes in the small intestine. The amount of energy required to achieve this state varies based on the type of food (or supplement), amount of food, quality and quantity of digestive enzymes, and stomach pH. This digestive process usually takes 6-8 hours.

The unique aspect of products made by Isotonix® is that the digestive process is acknowledged and addressed by providing nutritional supplements that the stomach doesn’t have to work on. Isotonix® nutrients are delivered into the stomach ready to be absorbed because they are already in an isotonic state. Therefore the beneficial elements are immediately available and quickly absorbed.

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60 Minutes reports on Resveratrol research

60_minutes

Click to view video at CBS.com

Last night, 60 Minutes aired a segment on resveratrol and the promise that it holds for extending life and reducing or preventing the diseases of old age.  60 Minutes chose to focus exclusively on the pharmaceutical research leading to an eventual drug–that Galaxo Smith Kline will patent and profit from.  They also only mentioned the research by Sirtris when there has been published studies and other significant research going on all over the globe and at major universities.

This is disappointing considering that you can get resveratrol today and start receiving the benefits immediately.  It makes me wonder if Dr. Sinclair agreed to be interviewed as long as 60 Minutes didn’t mention any of the other readily-available and natural alternatives.

What Makes Isotonix® Resveratrol Special?

Unique Vitamins and Antioxidants for Your Pets

After experiencing the benefits of potent antioxidants like Isotonix OPC-3® and Glucosatrin®, people petitioned for the similar products for their dogs and cats.  In response to those requests, a line of products called PetHealth™ was created.

dogPetHealth™ has unique vitamins, antioxidants and safe and effective grooming products that your dog or cat will thrive on.  In particular, the PetHealth™ OPC with Glucosamine also contains Pycnogenol® and is an amazing anti-inflammatory for animals that are experiencing joint pain and/or age related issues.

A friend of mine has a dog that had been suffering from chronic ear infections for over 6 months.  The vet had tried a variety of medications including several rounds of prednisone which only worked temporarily.  At her wits end she called me and asked about the PetHealth™ OPC.  I told her that steroids work by suppressing normal immune response which inhibits swelling and inflammation.  Unfortunately that suppression is accomplished through a massive free radical release.  So basically, the steroids temporarily reduce inflammation, but long term they create more cellular damage.

Apparently her dog had scratched his ears until they were bleeding, so my friend decided to try the PetHealth™ OPC rather than another round of steroids.  After giving her dog double doses, twice a day, she noticed improvement in less than a week.  After two and a half weeks her dog had healthy ears again and he was bounding up stairs that he hadn’t been able to climb since he was a much younger dog!

If you don’t really like the overpowering floral scent in a lot of dog shampoos, try the PetHealth™ Hypoallergenic or Medicated Shampoo.  These shampoos are sulfate-free, phosphate-free, alcohol-free, preservative-free and paraben-free leaving the dog with a silky coat and a subtle woodsy lavender scent.

What makes Curcumin Extreme unique?

I’ve posted several articles on the health benefits of curcumin, the powerful antioxidant found in the spice turmeric.  The product that my husband and I take is Curcumin Extreme™ from SHOP.COM (powered by Market America).  So what makes Curcumin Extreme™ different from other curcumin products on the market?

BCM-95®

One of the issues with curcumin is that it is not very bioavailable, which means that your body can’t readily absorb it.  Studies have shown that we can only absorb a small amount of curcumin when ingested.  However, a special formulation called BCM-95® by DolCas Biotech has been shown in clinical studies to be over 6 times more bioavailable than regular curcumin.  BCM-95® contains the natural spectrum of the turmeric rhizome and is 100% natural.

(Additional information on BCM-95 is available at www.bcm95.com)

Broccoli Seed Extract

Curcumin Extreme™ also includes 167mg of broccoli seed extract, a powerful source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of Phase II liver detoxification enzymes including glutathione synthase, heme-oxygenase and catalase. Sulforaphanes also support gene transcription, the process by which genetic information is copied from DNA to RNA. They also support the body’s natural defense systems. Glutathione is the master antioxidant in the human body which serves to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. Furthermore, glutathione recycles vitamins C and E which are also powerful antioxidants.

Related research:  Immunomodulatory activity of sulforaphane, a naturally occuring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine vol. 14: 538-545, 2006.

Selenium

Selenium is a required cofactor for selenoproteins such as glutathione peroxidase. Selenomethionine is incorporated directly into proteins because selenomethionine cannot be distinguished from methionine during the translation of mRNA into protein. This serves as a storage form of selenium and is liberated upon protein catabolism. Selenium accumulates in the prostate, promoting the health of the prostate. Selenium supports immune function by promoting normal growth and development of T helper cells.

Related research:  Selenium, selenoproteins and human health: a review. Public Health Nutrition vol. 4: 593-599, 2001

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