OPC-3 prevents arterial disfunction after eating a fatty meal

holiday-feastIt’s the holiday season, which means lots of food, not all of it healthy. Did you know that when you eat a fatty meal, the endothelial layer of your blood vessels becomes less effective at regulating blood-flow. This is why a high-fat diet can lead to hypertension and arterial sclerosis.

A new study by Dr Tom Barringer, Director of the Center for Cardiovascular Health at Carolinas Medical Center, evaluates the benefit of isotonic bioflavonoid supplementation in preventing impairment of endothelial dysfunction induced by a fatty meal. The researchers used OPC-3® with its high concentration of bioflavonoids. Using a sophisticated technique, Reactive Hyperemia Peripheral Arterial Tonometry in healthy adults, his research confirms that a fatty meal will transiently induce endothelial dysfunction which can then be protected by the ingestion of a complex bioflavonoid supplementation.

Dr. Barringer concludes:

“Our results indicate that the flavonoid supplement OPC-3® can reduce the acute impairment in endothelial function a high-fat meal. These findings do not imply that all the detrimental effects of a high saturated fat meal are neutralized by taking a flavonoid supplement. The standardized high-fat meal however is a convenient, reproducible means to induce endothelial impairment in healthy volunteers who otherwise have normal endothelial function as proven by their normal fasting values.”

Read the complete study

Isotonix OPC-3®

What makes Curcumin Extreme unique?

I’ve posted several articles on the health benefits of curcumin, the powerful antioxidant found in the spice turmeric.  The product that my husband and I take is Curcumin Extreme™ from SHOP.COM (powered by Market America).  So what makes Curcumin Extreme™ different from other curcumin products on the market?


One of the issues with curcumin is that it is not very bioavailable, which means that your body can’t readily absorb it.  Studies have shown that we can only absorb a small amount of curcumin when ingested.  However, a special formulation called BCM-95® by DolCas Biotech has been shown in clinical studies to be over 6 times more bioavailable than regular curcumin.  BCM-95® contains the natural spectrum of the turmeric rhizome and is 100% natural.

(Additional information on BCM-95 is available at www.bcm95.com)

Broccoli Seed Extract

Curcumin Extreme™ also includes 167mg of broccoli seed extract, a powerful source of sulphoraphane glucosinolates. Sulforaphanes support the normal production of Phase II liver detoxification enzymes including glutathione synthase, heme-oxygenase and catalase. Sulforaphanes also support gene transcription, the process by which genetic information is copied from DNA to RNA. They also support the body’s natural defense systems. Glutathione is the master antioxidant in the human body which serves to preserve and protect the brain and other body tissues by protecting them from the damage of free radicals. Furthermore, glutathione recycles vitamins C and E which are also powerful antioxidants.

Related research:  Immunomodulatory activity of sulforaphane, a naturally occuring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine vol. 14: 538-545, 2006.


Selenium is a required cofactor for selenoproteins such as glutathione peroxidase. Selenomethionine is incorporated directly into proteins because selenomethionine cannot be distinguished from methionine during the translation of mRNA into protein. This serves as a storage form of selenium and is liberated upon protein catabolism. Selenium accumulates in the prostate, promoting the health of the prostate. Selenium supports immune function by promoting normal growth and development of T helper cells.

Related research:  Selenium, selenoproteins and human health: a review. Public Health Nutrition vol. 4: 593-599, 2001

Pycnogenol selectively targets malignant ovarian cancer cells

Researchers at the Loma Linda University School of Medicine tested Pycnogenol on ovarian cancer cells and found that Pycnogenol induced apoptosis in the cancer cells, causing them to die, while not affecting normal ovarian cells at all.  This selectivity is very significant since it means that Pycnogenol may be useful as a chemopreventive agent against cancer.

I think that Pycnogenol, grape seed extract, resveratrol, curcumin and other natural substances are part of a new wave of preventative medicine that will significantly improve our health and extend our lives in the future.  Unfortunately, many medical professionals are not well informed about these alternatives and thus don’t recommend them to patients (or worse, suggest that they are not worth trying).  Instead, often the standard approach is only prescribing pharmaceutical substances that treat the disease after it is diagnosed.

Staying aware, and up-to-date, with ongoing research in holistic approaches can often work in concert with traditional treatments. Choosing the best from these two worlds is (in my opinion) the most intelligent approach.

Read the abstract

What makes Isotonix Resveratrol special?

I’ve posted several articles and studies about the remarkable effects of resveratrol, the compound in red wine (that is believed to be the answer to the “french paradox“), along with a link to Market America’s Isotonix® Resveratrol product.

With the increased awareness of the benefits of resveratrol, there are dozens of products popping up to cash in on the news including resveratrol beer!

So what makes Isotonix® Resveratrol different than all the others?  Quite a bit actually.


Isotonix® Resveratrol is the only resveratrol product that is isotonic-capable, which means that when it is dissolved in water it becomes isotonic.  Isotonic is a chemical state that means “same pressure” or “same concentration”.  The levels of dissolved solids in an isotonic solution match the fluids in the human body and are thus readily absorbed in the small intestine while retaining almost all of it’s nutritive value.


Isotonix® Resveratrol contains Resveravine®, a patented extract from Bio Serae Laboratories, that contains both trans-resveratrol and e-viniferin.  This synergistic combination has been shown in clinical studies to be more effective that regular resveratrol.

The following chart shows the effectiveness of various antioxidants, including resveratrol and Resveravine®, at inducing apoptosis (programmed cell death) in cancer cells.  Resveravine® is the red bar.

Frequency of apoptosis in tumor cells

Frequency of apoptosis in tumor cells (click for full size)

In another study, Resveravine® was found to be more effective at protecting LDL from free-radical oxidation damage than resveratrol and other antioxidants.

Protection from LDL oxidation

Protection from LDL oxidation (click for full size)

BioVin® Advanced

Isotonix® Resveratrol also contains BioVin Advanced®, a combination of resveratrol from French red wine, other wine polyphenols, and proanthocyanidins (OPCs).  If you’ve read the other posts on this forum about OPCs, you know what a powerful combination this is.


The final active ingredient of Isotonix® Resveratrol is VitaBlue™, a patented blueberry extract made from North American wild blueberries.  Blueberries have long been touted as a potent antioxidant, but also contain a compound called pterostilben, a relative to resveratrol that has been shown to have anti-cancer, cholesterol reduction, and cognitive improvement effects.  VitaBlue™ also provides anthocyanins (12.5%), polyphenolics (40%), and has an extremely high total ORAC value of 6500 units per gram.

The combination of Resveravine®, BioVin® Advanced, VitaBlue™, and isotonic capability make Isotonix® Resveratrol an extremely potent and highly bioavailable form of resveratrol that is unique in the industry.

Isotonix® Resveratrol

Wikipedia on isotonicity

Curcumin may treat intractable brain tumor

The January 2008 issue of Life Extension Magazine reported that recent research has found curcumin may be a useful adjutant therapy in the treatment of glioblastoma, a difficult-to-treat form of brain cancer.  Malignant gliomas are aggressive tumors due to their resistance to chemotherapy and radiation.

The researches examined the effect of curcumin on various human and rodent glioma cells lines in the laboratory.  Curcumin reduced the survival of cancerous cells and also made the cells more sensitive to chemotherapy agents and radiation.

Learn about Curcumin Extreme™ with BCM-95® and broccoli seed extract.

Several studies document curcumin’s cancer fighting properties

boxingScientists are discovering that curcumin, and ingredient of the spice turmeric, has properties that fight cancer.  Most of the studies are in the lab using cancer cells or laboratory mice and controlled doses of curcumin, but the findings are very exciting.

Turmeric may help stop the spread of breast cancer (Clinical Cancer Research, 2005)

Curcumin in curry fights against melanoma (Cancer, 2005)

Curcumin fights colorectal cancer (Clinical Cancer Research, 2006)

Curcumin Extreme™

Curcumin reduces heart enlargement and may prevent heart failure

Fresh turmeric roots

Curcumin is a natural ingredient in the spice turmeric, which has been used for centuries in traditional Indian and Chinese medicine. Western science has only recently discovered its benefits.

Researchers at the Peter Munk Cardiac Centre of the Toronto General Hospital have discovered that “curcumin prevents and reverses murine cardiac hypertophy,” which is enlargement of the heart. It also was able to restore heart function and reduce scar formation.

According to cardiologist Dr. Peter Liu, curcumin works by shutting off one of the major switches right at the chromosome source where the enlargement and scarring genes are being turned on.

Read the complete article

Learn about Market America’s Curcumin Extreme™

Resveratrol may help Multiple Sclerosis

wheelchairA study conducted by researchers at the University of Utah, found that resveratrol helped with certain symptoms of an MS-like disease in laboratory mice.  While this research is preliminary, and effects on mice do not imply similar results in humans, it is another promising discovery on resveratrol’s pro-health benefits to living organisms.

Read complete article

Resveratrol is one of many potent antioxidants that stimulates our bodies to produce glutathione. Increasing glutathione production and subsequently controlling free radical damage is being studied as another promising treatment for MS.

Isotonix® Resveratrol
Isotonix® Vitamin D with K2

Top 6 reasons to take CoQ10

heart-healthCo-enzyme Q10 is a vital compound that your body creates naturally that allows cells to generate energy. It is particularly beneficial to the heart. Jimmy Moore, a writer for the San Francisco Examiner, came up with the following top-6 reasons for supplementing your diet with CoQ10:

  1. It naturally lowers your blood pressure.
  2. Destroy cell-damaging free radicals.
  3. Reduces oxidized fat that leads to clogged arteries.
  4. Alleviates major heart health risk factors.
  5. Reduces pain felt by chronic stable angina patients.
  6. Regulates the rhythm of your heart rate.

Read the full article.

There is also evidence that CoQ10 is more easily absorbed by the body if it is first dissolved in the mouth. SHOP.COM (powered by Market America) provides two different products with highly bioavailable forms of high-quality CoQ10:

Heart Health™ Advanced CoQ10  – Thirty servings of softgel tablets
Isotonix Coenzyme Q10 – Thirty servings of a drinkable isotonic solution with up to 95% absorption

Antioxidants may protect against eye disease

A study published in the Journal of Biological Chemistry finds that antioxidants “disrupt a link between two beautiful-eyeprocesses in the retina that, in combination, contribute to macular degeneration. Antioxidants also extend the lifetime of irreplaceable photoreceptors and other retinal cells.”

Antioxidants included in the study include Vitamin E, Vitamin C, resveratrol, and bilberry extract.

Link to news article (Forbes.com)

Complete study results

Isotonix® Resveratrol
Isotonix® Vision Formula with Lutein
Astaxanthin Cardio and Visual Vitality Formula

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