Resveratrol increases repair and protection of cells by 8 fold

Resveratrol is a potent antioxidant compound found in red wine grape skins and seeds. Resveratrol is also found in various amounts in several other types of plants and acts as a protective agent defending the plant from harmful environmental elements.

Several studies show that resveratrol also enhances human immune function and potential longevity. Well, the news on resveratrol continues to pour in with yet another significant benefit provided by this compound being touted in a new study.

A normal function that cells perform is folding proteins.  When cells misfold proteins and the immune system doesn’t catch them, the misfolded proteins set the stage for trouble.

Cells that experience stress, respond by producing “heat-shock proteins”.  These proteins were called SIRT1. These SIRT1 heat-shock proteins were given that name when it was observed that cells exposed to elevated temperatures generated these special proteins to protect and repair DNA and extend the life of the cell. Cells with SIRT1 activated are stronger, live longer and continue to perform their functions under stress.

Other types of cellular stress like calorie reduction and oxygen-deprivation also triggers SIRT1.  Resveratrol has shown a unique ability to stimulate SIRT1 production by as much as 8 fold without the presence of typical cell stress like heat, food reduction or reduced oxygen.

Resveratrol is plant compound found in grapes that has antioxidant abilities which neutralize free radicals and has demonstrated cancer preventative properties. By triggering SIRT1 production, it holds the potential for increasing life span by protecting cells and inhibiting age related disease.

Neurodegenerative diseases like Type II diabetes, Alzheimer’s and Parkinson’s all present significant amounts of misfolded protein cellular damage.  When SIRT1 levels fall cells are unable to properly respond to stress and systems of the body start to fail.  This also happens during the aging process.

According to research team leader, Richard I. Morimoto, professor of Northwestern’s Weinberg College of Arts and Sciences “When SIRT1 levels are high, you are in a high-protection mode”. Resveratrol contributes to high SIRT1 levels.

“We now have a powerful way to think about addressing neurodegenerative diseases,” said Morimoto. “We have identified a pathway that can be manipulated to alter lifespan. Discovering this new basis for therapeutics is very exciting.”

Isotonix® Resveratrol

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