Cognitive deterioration may be prevented or reversed with Resveratrol

old-guy-eating-grapesThe aging process, along with several neurodegenerative diseases, causes synaptic deterioration in the brain.  As neurons and brain cells die off, connections are lost impacting learning and memory retention.  Doctors studying Alzheimer’s and other types of age-related dementia are encouraged by a new study on how resveratrol reversed cognitive deterioration in laboratory tests.

In addition to protecting cell health and longevity, SIRT1 is a gene that our bodies trigger when under various types of stress.  SIRT1 activation was initiated in mice that had developed comparable human neurodegenerative diseases.  The mice were treated with resveratrol, which reduced the rate of neuron and cell death and restored learning abilities back to the same level as the normal healthy mice.

“Thus, resveratrol is not only neuroprotective, it also improves cognitive function after severe neurodegeneration,” says Li-Huei Tsai, the research team leader and professor of neuroscience at MIT.

Previously it was thought that resveratrol could not cross the blood brain barrier, however a study done in 2002 indicated otherwise.  In fact, the final summary line stated:  “This study demonstrated for the first time that resveratrol, a polyphenolic antioxidant, can cross the blood-brain barrier and exert protective effects against cerebral ischemic injury.” (An ischemic injury is caused by insufficient oxygen or blood flow).

Resveratrol offers yet another safe and natural benefit that could actually improve cognitive function in cases of neurodegenerative disease.

Isotonix® Resveratrol


  1. Linda said,

    April 1, 2009 at 1:34 am

    Have you had a chance to watch 60 Minutes or Barbra Walters segments last weekend about it?

    It show promise in mice. For mice, has shown major health improvements including blood sugar control. Keep in mind that 6 out of 10 major drug successes in mice – fail in humans. But the limited human trials showed promise and there are some patients that claim it helps. However, this could be the ‘placebo effect,’ and only empirical data under controlled experiments can tell for sure. It will take a few years for these clinical trials to conclude.

    You can get supplements of the extract right now. While it is safe, it is not guaranteed to work. Before making a decision, you should watch all the videos.

    I did some research and learned the following: You can only get 1-2mgs of it in a single bottle of wine. So, white, it’s a good excuse to drink wine, but you really won’t get much benefit. There are supplements on the market – but many do not have the required strength and they don’t work for everyone. The only way to know for sure is to try the supplements. Hope you find this interesting… its a future hope for the fountain of youth and treatments (not cures) for countless diseases.

  2. engineeredforhealth said,

    April 1, 2009 at 4:17 am

    The two 60 Minutes TV shows on resveratrol aired the beginning of 2009 and last year in 2008. In them I found it very interesting how the focus was exclusively on the creation of a synthetic pharmaceutical version of resveratrol. Dr. Sinclair’s enthusiasm no doubt stems from the fact that only synthetic compounds can be patented, which is the main way drug companies make money. Rather than wait years for the synthetic version, natural forms of resveratrol are available right now. However, your warning about finding a high quality version is very relevant. My post “Deciphering Labeled Amounts of Resveratrol” discusses that predicament.

    Regarding the use of mice as murine models for scientific study, the National Human Genome Research Institute has an interesting paper on mice. They say: “Scientists from a wide range of biomedical fields have gravitated to the mouse because of its close genetic and physiological similarities to humans, as well as the ease with which its genome can be manipulated and analyzed.” The National Human Genome Institute also goes on to provide an impressive list of diseases that mice models have provided understanding and existing treatments for. The list includes: Downs Syndrome, Cystic Fibrosis, Breast Cancer, Glaucoma, Type 1 & 2 Diabetes, Epilepsy, Heart Disease, Musclular Dystrophy and Ovarian Tumors. You can find their paper here:

    So while studies of the known and unknown benefits of resveratrol continue, it is clear that resveratrol is a potent antioxidant. That, alone is an excellent reason to use this amazing compound. I personally promote Isotonix Resveratrol because it is isotonic, making it extremely easy to absorb and receive the full benefit from the product. Also, it is made at GMP (Good Manufacturing Practices) labs. That provides assurance of its sources, purity, standardization and potency. See my post on “What Makes Isotonix Resverstrol Special” for more information.

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